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MRSA and Children

Understanding MRSA. (Mersa or Staph)

MRSA Watch has gathered over 4500 articles on MRSA into a unique directory - see A-Z  guide in right hand column. Our written MRSA Basics guide below is a definitive guide to the infection and how to respond. You might prefer the audio introduction below 

Ask an MRSA question * MRSA News Headlines *MRSA in your town

 

Simple staph aureus (SA) bacteria, (mrsa is not a virus), can be found on the bodies of up to 30% of the general population. It caused many problems before the use of antibiotics made wound recovery a safer process. Hospital acquired staph is generally resistant to several antibiotics but especially Methicillin, hence the name MRSA. This is found in about 1% of the population but in some pockets of the population this figure can be much higher.

Super_bug_091404Image from Komo News

Community Acquired MRSA (CA MRSA) is a different strain of MRSA, mainly causes skin infections and is treatable by more drugs at this time. CA MRSA (sometimes known as Mersa or Mursa) is more infectious and some strains of it are more destructive - should it become resistant to more antibiotics it could pose a considerable public health risk. Many people carry or are 'colonised' by staph bacteria but only suffer when they have another illness.

The colonisation stage carries no symptoms. Many only suffer MRSA as an infection of an existing wound. In recent times however some types of CA MRSA have begun to cause significant skin infections in otherwise healthy patients. The entry point is often a tiny cut, graze or exisiting skin condition.

 

How do people catch MRSA?
There are several ways it is believed to spread.

  • Hand carriage - this is why hospital staff are encouraged to wash their hands after each patient.
  • Contaminated surfaces - this is why clean hospital wards are vital.
  • Via medical instruments - this is why many now have special coatings or have silver elements. This discourages lingering residues and/or kills external infection entering the wound
  • Via airborne particles - MRSA often resides in the nasal passages and can spread with colds and flu as a secondary infection that may be dormant for some while.
  • Shared items - Families or other close knit groups sharing a facility such as military personnel, a sports team or prison inmates may share hygiene items such as towels etc. This is another vector for the spread of the bacteria
  • Needles - Drug users sharing needles may be passing on MRSA alongside HIV or Hepatitis C. The same could be said of tattoo artists who do not have strict hygiene regimes.
  • Sexual Intimacy - the nose, groin and underarms are key colonisation areas for the bacteria. Sex workers and the habitually promiscous will be super spreaders in a society in much the same way as they are for AIDS.

How is it treated?
There are 3 key treatment regimes that are commonly used.

  • For those who are colonised - a nasal treatment and a skin wash. This is often the strategy when MRSA is rare or prior to an operation as a means of preventing infection. Where MRSA is common some doctors will not suggest decolonisation as many will be recolonised within months within the local community. Some deep seated - throat and intestine - colonisation may require drug treatment.
  • For those who have a potential or active bloodstream infection - drugs such as Vancomycin, Linezolid or Daptomycin.
  • For those with infected wounds - special honey, silver bandages, garlic preparations and tea tree oil are all believed to be effective in killing MRSA in a wound. Many who have the skin infections common with CA MRSA simply need incision and drainage of the infected area and good hygiene while it heals. Antibiotics are not always needed.

How can it be prevented
The media often focus on clean hospitals and clean hands as a key to combating MRSA. Others believe that this will only cut cases by 30% and that a diverse strategy is vital and will include:

What can I do

  • Stay informed - this site and several others can help you do this. The A-Z guide in the right hand column will give you in depth information on over 50 aspects of MRSA from over 4000 articles, news items and academic papers.
  • Ask others via our MRSA Watch forum
  • Act locally by becoming involved in patient advocacy or patient/hospital forums
  • Seek justice - do you need to take legal action because of neligence or do we all need to speak up for communities who are being hit by CA MRSA but are underinsured and often powerless.

 

MRSA Headlines

High prevalence in cystic fibrosis patients of multiresistant MRSA

Link: High prevalence in cystic fibrosis patients of multiresistant hospital-acquired methicillin-resistant Staphylococcus aureus ST228-SCCmecI capable of biofilm formation -- Molina et al., 10.1093/jac/dkn302 -- Journal of Antimicrobial Chemotherapy.

Conclusions: Distinct microbiological and molecular features were detected among CF-MRSA isolates, probably due to adaptation to specific conditions in CF patients. Prevalence of MRSA increased among these patients, most of them colonized with a multiresistant biofilm-forming clone belonging to ST228-SSCmecI, suggesting cross-transmission or a common source.

MRSA Impact on Chidren Worsening

Link: HighWire Press -- Medline Abstract.

RESULTS:: Two hundred ninety children (60% male subjects) with acute osteomyelitis were identified. Median (25th-75th percentile) age at diagnosis was 6 years (range, 2-11 years). Significant clinical findings included the following: localized pain (84%), fever (67%), and swelling (62%). Affected bones included the following: foot (23%), femur (20%), tibia (16%), and pelvis (7%). Thirty-seven percent of blood cultures were positive, and a bacterial isolate was obtained in 55% of cases. Bacteria most frequently isolated included the following: methicillin-sensitive S. aureus (45%) (57% in period Avs 40% in period B), MRSA (23%) (6% in A vs 31% in B; P < 0.001), Streptococcus pyogenes (6%), and Pseudomonas aeruginosa (5%). Children with MRSA compared with those with non-MRSA osteomyelitis had significantly greater erythrocyte sedimentation rate and C-reactive protein values on admission and increased length of hospital stay, antibiotic therapy, and overall rate of complications. We observed significant changes in antibiotic therapy related to increased use of agents with activity against MRSA. CONCLUSIONS:: Methicillin-resistant S. aureus was isolated more frequently in the second study period and was associated with worse clinical outcomes. LEVEL OF EVIDENCE:: II. Retrospective study.

Babies Isolated For Colonised MRSA Outbreak

Link: Babies Isolated For Colonised MRSA Outbreak (from The Herald ).

Five newborn babies on an intensive care ward have been isolated after the MRSA bug was found on their skin. Another seven babies in the unit who were unaffected by the outbreak were immediately moved to temporary accommodation at the Royal Alexandra Hospital in Paisley to prevent the bug from spreading. The five affected infants are being looked after in isolation in the hospital's special care baby unit. None has been infected by the bug but they have colonised MRSA, which means the bacteria has simply lodged on their skin. Most people with colonised MRSA experience no symptoms and require no treatment.

Baby ward cleared of superbug

Link: Baby ward cleared of superbug - ABC News (Australian Broadcasting Corporation).

The Newborn Care Centre at Sydney's Royal North Shore Hospital has reopened its doors after five babies tested positive to an antibiotic-resistant superbug. The babies were isolated more than a week ago, after doctors found the MRSA bacteria on their skin or inside their noses. The hospital says none of the babies became ill but the centre was closed to new admissions as a precaution. A hospital spokeswoman says there have been no new infections and the ward has been back to normal since Friday night. The MRSA superbug can be transferred between patients when hospital staff do not follow proper sanitary procedures.

The MRSA time bomb growing among children

Link: Prevalence of and Risk Factors for Community-Acquired Methicillin-Resistant and Methicillin-Sensitive Staphylococcus aureus Colonization in Children Seen in a Practice-Based Research Network -- Fritz et al. 121 (6): 1090 -- Pediatrics.

OBJECTIVE. We sought to define the prevalence of and risk factors for methicillin-resistant Staphylococcus aureus nasal colonization in the St Louis pediatric population. METHODS. Children from birth to 18 years of age presenting for sick and well visits were recruited from pediatric practices affiliated with a practice-based research network. Nasal swabs were obtained, and a questionnaire was administered. RESULTS. We enrolled 1300 participants from 11 practices. The prevalence of methicillin-resistant S aureus nasal colonization varied according to practice, from 0% to 9% (mean: 2.6%). The estimated population prevalence of methicillin-resistant S aureus nasal colonization for the 2 main counties of the St Louis metropolitan area was 2.4%. Of the 32 methicillin-resistant S aureus isolates, 9 (28%) were health care-associated types and 21 (66%) were community-acquired types. A significantly greater number of children with community-acquired methicillin-resistant S aureus were black and were enrolled in Medicaid, in comparison with children colonized with health care-associated methicillin-resistant S aureus. Children with both types of methicillin-resistant S aureus colonization had increased contact with health care, compared with children without colonization. Methicillin-sensitive S aureus nasal colonization ranged from 9% to 31% among practices (mean: 24%). The estimated population prevalence of methicillin-sensitive S aureus was 24.6%. Risk factors associated with methicillin-sensitive S aureus colonization included pet ownership, fingernail biting, and sports participation. CONCLUSIONS. Methicillin-resistant S aureus colonization is widespread among children in our community and includes strains associated with health care-associated and community-acquired infections.

HIV Children Very Vulnerable to Infection

Link: HighWire Press -- Medline Abstract.

Seventy-seven percent of S. aureus were MRSA. Carriage of resistant organisms was not associated with hospitalization. On multivariate logistic regression, risk factors for colonization with Enterobacteriaceae were age below one year (Odds ratio 4.4; 95% Confidence Interval 1.9-10.9; p = 0.0008) and CDC stage C disease (Odds ratio 3.6; 95% Confidence Interval 1.5-8.6; p = 0.005) Nineteen (9.4%) subjects had 23 episodes of bacteremia. Enterobacteriaceae were most commonly isolated (13 of 25 isolates), of which 6 (46%) produced ESBL and were resistant to gentamicin. CONCLUSIONS: HIV-infected children are colonized with potential pathogens, most of which are resistant to commonly used antibiotics. TMP-SMX resistance is extremely common. Antibiotic resistance is widespread in colonizing organisms and those causing invasive disease. Antibiotic recommendations should take cognizance of resistance patterns. Antibiotics appropriate for ESBL-producing Enterobacteriaceae and MRSA should be used for severely ill HIV-infected children in our region. Further study of antibiotic resistance patterns in HIV-infected children from other areas is needed.

In memory of Maddy: MRSA claims life of two month old

Link: In memory of Maddy :: Naperville Sun :: Lifestyles.

Thirty-six hours before Madeline Reimer stopped breathing, her mother snapped a photo of the newborn, sleeping serenely on a pastel blanket in the summer of 2005. Displayed in the stairway of her Plainfield home, it's one of the only photos of her with her eyes closed. In most others, her big, dark eyes are focused on her twin brother, Luke. Her mother, Beth Reimer, looks more closely at the photo today. Maddy's tiny nostrils are flared - possibly because she was struggling to breathe, Beth said. Her parents and her pediatrician thought she had a cold at the time, but a strain of drug-resistant bacteria was eating away at her lungs.

MRSA Children Should Get Flu Shots

Link: State: Flu bug is hitting hard here.

Is anything different about this year's flu? Many cases seem shorter, but more severe, Sinnott said. Health officials also are watching for bacterial infections following the flu, often the most deadly complication of the disease. Last year, Florida had a few cases of flu-associated pneumonia caused by MRSA, a type of staph bacteria that is resistant to most antibiotics. Doctors will be watching for that closely this year. Dumois has advised families where children have had MRSA infections to get flu shots.

Child At Day Care Diagnosed With MRSA

Link: Child At Day Care Diagnosed With MRSA - Orlando News Story - WKMG Orlando.

A child who attends a Central Florida day care has been diagnosed with methicillin-resistant Staphylococcus aureus infection, more commonly known as MRSA, according to officials. The infection, caused by Staphylococcus aureus bacteria or staph, was discovered in a room for 2 year olds at Kids-R-Kids in Waterford Lakes, officials said.

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