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CDC-funded studies went on to show that daily chlorhexadine (CHG) bathing can significantly reduce contamination of patient’s skin, the environment, and HCP hands, with organisms such as MRSA and VRE. Reductions in spread of MRSA and VRE have been documented using this strategy, and there at least two separate studies showing reduction in bloodstream infections. It is also encouraging that the experience to date suggests this strategy is simple for hospitals to implement and is well tolerated by patients. The CDC Prevention Epicenter Program has made possible two separate randomized controlled trials to further examine this promising approach to preventing HAIs. We look forward to the results of those studies.