Antimicrobial Activity of Ceftaroline and ME1036

Link: Antimicrobial Activity of Ceftaroline and ME1036 Tested against Clinical Strains of Community-Acquired Methicillin-Resistant Staphylococcus aureus (CA-MRSA) -- Sader et al., 10.1128/AAC.01351-07 -- Antimicrobial Agents and Chemotherapy.

Two investigational anti-methicillin-resistant Staphylococcus aureus (MRSA) {beta}-lactams, ceftaroline (cephalosporin) and ME1036 (carbapenem) were susceptibility tested by reference broth microdilution methods against 152 strains of community-acquired MRSA (CA-MRSA) from the United States (47 medical centers). Ceftaroline and ME1036 were 64- and >128-fold more potent that ceftriaxone, respectively. All isolates had the PVL genes and SCCmec type IV, while 67.8% of isolates showed PFGE clonal type USA300-0114.